S. Jacobs, H. Rosenkranz
Apr 1, 1970
Citations
0
Influential Citations
36
Citations
Journal
Cancer research
Abstract
Summary Exposure of DNA to hydroxyurea resulted in degradation of the polydeoxynucleotide. This reaction is dependent upon time, temperature, and pH and has been associated with the transformation of hydroxyurea to a reactive derivative. Addition of the reactive derivative to DNA resulted in rapid degradation. Preliminary findings suggest that N -carbamoyloxyurea is the transformation product in the reactive derivative responsible for DNA degradation.