M. B. Devani, C. Shishoo, H. J. Mody
Sep 1, 1974
Citations
0
Influential Citations
6
Citations
Journal
Journal of pharmaceutical sciences
Abstract
2,3-Dichloro-1,4-naphthoquinone is reacted with thioamides in microquantities in the presence of ammonia in an alcoholic medium to give colored products showing absorbance maxima between 530 and 540 nm. The reaction is specific for thioamides and forms the basis of its spot test. The reaction is also used for the quantitative determination of ethionamide in tablets. The results compare favorably with those obtained by the official BP method. The method is simple, accurate, and precise.