F. S. Chiccarelli
Jun 1, 1968
Citations
0
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Citations
Journal
Journal of pharmaceutical sciences
Abstract
6-Demethyltetracycline, when heated with nitric acid, forms a stable colored derivative having an absorption maximum at 425 mμ. 6-Demethylchlortetracycline under the same condition is unstable. When 6-demethylchlortetracycline is heated with nitric acid, the color produced by the 6-demethyltetracycline fraction can be measured directly or extracted with n -butanol.