Yang Jian-yun
2011
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Journal
Pharmaceutical Journal of Chinese People's Liberation Army
Abstract
Objective To establish an high performance liquid chromatography method for the determination of 7-methoxy-1-tetralone and its related substances.Methods The analysis was carried out on a Dikma Diamonsil C18(5 μm,4.6 mm×250 mm)column and a mobile phase of methanol-water(68∶32).The flow rate was 1.0 ml/min,and the detection wavelength was set at 222 nm.Results 7-methoxy-1-tetralone and its related substances were completely separated within a linear range of 8-32 μg/ml(r=0.9996).The detection limit of 0.8ng was obtained,with related substances less than 1%.Conclusion This method is simple,accurate,and reproducible,which can be used to determine 7-methoxy-1-tetralone.