Feng Ming-mei
2007
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Journal
Journal of Modern Food and Pharmaceuticals
Abstract
Objective To establish a HPLC method for determination of Cefonicid Sodium and its related substances.Methods The separation was performed on Kromasil 100A C18column(150 mm×4.60 mm,5 μm)the mobile phase was methanol-0.025 mol/L monobasic ammonium phosphate(15∶85)with flow rate of 1.0 ml/min.The column temperature was at 40 ℃ with detection wavelength at 272 nm.Results The detection limit of Cefonicid Sodium was 1.0 ng.The linearity was in the range of 0.10~0.30 mg/ml with RSD less than 0.17%(n=5).Conclusion The method is simple,rapid,accurate and reproducible,and it can be used for quality control of cefonicid sodium.