H. Li, M. Johnston, D. Mufson
Dec 1, 1977
Citations
0
Influential Citations
5
Citations
Journal
Journal of pharmaceutical sciences
Abstract
A sensitive and specific GLC method for the determination of urinary chlorthalidone levels was developed using on-column methylation. Chlorthalidone is converted to a tetramethylated derivative with trimethylanilinium hydroxide in methanol. This method which permits the determination of as little as 0.1 microgram of chlorthalidone/ml of dog urine, should be adequate for use with human subjects receiving a clinical dose.