T. F. Brodasky, F. Sun
Mar 1, 1974
Citations
0
Influential Citations
6
Citations
Quality indicators
Journal
Journal of pharmaceutical sciences
Abstract
Clindamycin 2-palmitate, used in pediatric formulations, is readily hydrolyzed to clindamycin. During clinical investigations of this antibiotic, it was necessary to determine if unhydrolyzed clindamycin palmitate was present in the serum of clinical subjects. Chemical and enzymatic hydrolyses were unsuitable and instrumental techniques were ultimately developed. Two methods are described, one based on a combination of GLC and single-ion focused mass spectroscopy and a second using TLC and GLC. Examination of human serum from subjects receiving 300–600 mg clindamvcin base equivalents of clindamycin palmitate hydrochloride revealed no statistically significant quantities of unhydrolyzed clindamycin palmitate.