Wang Li, Li Hua
2007
Citations
0
Influential Citations
2
Citations
Journal
Journal of Northwest University
Abstract
Aim To establish an HPLC method for the determination of content of compound pramoxine hydrochloride cream.Methods A CLC-ODS C18 column(150 mm×4.6 mm,5 μm) and acetonitrile-phosphate buffer solution(55:45) as the mobile phase(adjusted to pH 7.5) were used for the determination with the detection wavelength of 224 nm and the column temperature of 40℃.The flow rate was 1.0 mL/min.Results A linear relationship was obtained with the range of 0.212 0~0.903 5 mg/mL(r=0.999 9).The average recovery was 99.63%(RSD=0.53%).Conclusion The method is simple,sensitive,accurate and suitable for the quantitative control of compound pramoxine hydrochloride cream.