Feng Song-ye
2008
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Journal
Chinese Journal of Pharmaceutical Analysis
Abstract
Objective:To establish a gradient elution HPLC method for determination of the contents and related substances in ergonovine maleate and its tablets.Method:The column was ODS-3 (250 mm×4.6 mm,5μm). Mobile phase A:0.015 mol·L~(-1)potassium dihydrogen phosphate buffer (pH 3.0):acetonitrile was 86:14;Mobile phase B:0.015 mol·L~(-1)potassium dihydrogen phosphate buffer (pH 3.0):acetonitrile was 70:30.Flow rate:1.2 mL · min~(-1).Detection wavelength:314 nm.Results:The calibration curve was linear in the range of 2.5-20.0 μg ·mL~(-1)(r=0.9998).Conclusion:The method is simple,sensitive,specific,reproducible,accurate and suitable for examination of the contens and related substances in ergonovine maleate and its tablets.