H. Xin
2008
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Journal
Food and Drug
Abstract
Objective To establish a HPLC method for the determination of diisopropylamine dichloroacetate in Compound Diisopropylamine Dichloroacetate and Sodium Chloride Injection.Methods A C18 column was used with the mobile phase of perchloric acid solution(0.82?1000 mL,add 2 mL of triethylamine and regulate pH to 3.0 with phosphoric acid)-acetonitrile(97:3) at the detection wavelength of 215 nm with the flow rate of 1.0 mL/min.Results The calibration curve was linear in the range of 0.48~1.12 mg/mL.The average recovery was 100.3% with RSD of 0.37%.Conclusion The method is simple and accurate and it can be used for the quality control of Compound Diisopropylamine Dichloroacetate and Sodium Chloride Injection.