Guanxiang Yuan, Zhou Zhu, Peng Yang
Jun 1, 2020
Citations
2
Influential Citations
16
Citations
Journal
Journal of Food Composition and Analysis
Abstract
Abstract Illegal use of nitrofurans (NFs) in aquaculture is of great concern for food safety throughout the world. A liquid chromatography-based method coupled to tandem mass spectrometry was developed and validated for measuring levels of four conventional NFs (nitrofurantoin, furazolidone, nitrofurazone, and furaltadone) and four additional NFs (nifursol, nifuroxazide, nifurpirinol, and sodium nifurstyrenate) in shellfish and fish samples. Limits of detection and quantitation were 0.01–0.2 µg/kg and 0.04–0.5 µg/kg for seven NFs, except for sodium nifurstyrenate (2 µg/kg and 5 µg/kg). Recoveries were 91.6–107.3 % with inter-day and intra-day relative standard deviations in the range of 0.8–9.6 % and 0.7–10.7 %, which were assessed at four fortification levels. The validated method was applied to 397 shellfish and 140 fish collected from South China in 2014−2017. The total non-compliant rate (>1.0 µg/kg) of the four major NFs was 4.3 % in shellfish (