C. Gan
2014
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Journal
Journal of Anhui Agricultural Sciences
Abstract
[Objective]A high performance liquid chromatography( HPLC) method was established to determine the eight volatile carbonyl compounds( formaldehyde,acetaldehyde,acetone,acrolein,propionaldehyde,crotonaldehyde,2-butanone,and butyraldehyde) in the refill liquids for electronic cigarettes. [Method] After carbonyl compounds in the refill liquids were reacted with 2,4-dinitrophenylhydrazine( DNPH) in an acidic medium to form 2,4-dinitrophenylhydrazone derivatives,which were separated on DIONEX Acclaim Explosive E2 column( 250 mm × 4.6 mm,5 μm) under the gradient elution with acetonitrile and water as mobile phase,and analyzed with a ultraviolet detector.[Result]The eight volatile carbonyl compounds had good correlation coefficients( R2 more than 0. 999) in corresponding concentration ranges,the average spiked recoveries ranged from 96. 4% to 101. 1% with a relative standard deviation lower than 3. 26%,and the limit of detection is between 0. 009- 0. 035 mg /L. [Conclusion]The developed method featured simple pretreatment,high sensitivity,good accuracy and precision,and it is successfully applied for the simultaneous determination of the eight carbonyl compounds in refill liquids