Liu Ya-feng
2008
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Journal
Journal of Instrumental Analysis
Abstract
A method has been developed to determine moroxydine hydrochloride in animal tissue by hydrophilic interaction chromatography with tandem mass spectrometry.Sample was precipitated and extracted by trichloroacetic acid solution.Sodium heptane sulfonate was used as the ion-pair reagent and the sample clean-up was achieved with solid-phase extraction column.Finally,it was determined by LC-MS/MS and multiple reactions monitoring,using positive electrospray ionization and external standard method.The recovery ranged from 60% to 107% fortified with 5-100 μg/kg moroxydine in various matrix and RSD was in the range of 5.8%-12%;the limits of detection(LOD) and limits of quantification(LOQ) were 2,5 μg/kg.This method is suitable for determination of moroxydine in animal tissue.