D. Burke, V. Venturella, B. Senkowski
Feb 1, 1974
Citations
0
Influential Citations
7
Citations
Journal
Journal of pharmaceutical sciences
Abstract
A colorimetric method for the determination of phenylpropanolamine hydrochloride, based on the reaction with ninhydrin, was applied to various forms of pharmaceutical products. The method is applicable to pharmaceutical products that do not contain other primary or secondary amines. The determination is dependent upon the combined hydroxyl and primary amino moieties. It is postulated that phenylpropanolamine hydrochloride reacts with ninhydrin under the experimental conditions by a mechanism similar to that for amino acids. A comparison of the molar absorptivities of phenylpropanolamine hydrochloride with those of amino acids, such as glycine and phenylalanine, clearly demonstrates the similarity of the reaction mechanism to the classic ninhydrin mechanism.