S. B. Zak, H. Tallan, G. Quinn
Sep 1, 1963
Citations
0
Influential Citations
31
Citations
Journal
The Journal of pharmacology and experimental therapeutics
Abstract
An extremely sensitive spectrofluorimetric method has been developed for the separate estimation of dipyridamole and of its metabolites in biological fluids and tissues. See table in the PDF file The half-life of dipyridamole in rabbit plasma is 75 minutes and the drug disappears rapidly from the tissues as well. Dipyridamole glucuronides were found in plasma and, unexpectedly, in tissues. A second metabolite of dipyridamole has been found in the bile and identified as dipyridamole diglucuronide.