W. D. Mason, E. N. Amick, Orville H. Waddle
Dec 19, 2006
Citations
0
Influential Citations
1
Citations
Journal
Analytical Letters
Abstract
Abstract The resolving power of high pressure liquid chromatography has been combined with the sensitivity of fluorescence detection to develop a method for the determination of propranolol and 4-hydroxypropranolol in plasma. A single selective extraction step precedes chromatography on a high efficiency bonded phase column. The limits of quantitation are approximately 2 ng/ml of plasma for each drug. The analysis of a number of clinical samples has demonstrated the application of the method in pharmacokinetic studies, but the possible interference of other drugs and their metabolites is still under investigation.