W. Xin
2009
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Journal
Chinese Journal of Analysis Laboratory
Abstract
Normal-phase chromatographic model was employed for enantionmeric separation of(R)-N-acetylthiazolidine-2-thione-4-carboxylic acid derivatives on the Chiralcel OD-H column in hexane/isopropyl alcohol mobile phase.The effects of chromatographic conditions such as mobile phases and temterature to chiral recognition of the N-acetylthiazolidine-2-thione-4-carboxylic acid detrivatives have been investigated.The optimal conditions of analysis were obtained and the separation factor was more than 1.3.Furthermore,the result of the determination by polarimetry was consistent with that by HPLC and the relative deviation was not more than 1.9%.