W. Soine
1981
Citations
0
Influential Citations
1
Citations
Journal
Journal of pharmaceutical sciences
Abstract
A common contaminant of illicit phencyclidine, 1-piperidinocyclohexanecarbonitrile (I), is a very weak base compared to tertiary amines such as phencyclidine, 1-(cyclohexenyl)piperidine, and piperidine. Compound I and its hydrobromide salt can be selectively detected and quantitated in the presence of synthetic contaminants by nonaqueous titration with perchloric acid in acetonitrile. This method allows direct assay of I under conditions where decomposition is not observed.