Liang Ming
2013
Citations
0
Influential Citations
3
Citations
Journal
Journal name not available for this finding
Abstract
Ranitidine hydrochloride (RNH), chemically N-[2-[[[5[(dimethylamino)methyl]-2-furanyl] methyl]thio]ethyl]-N'methyl-2-nitro-1,1-ethenediamine hydrochloride (Fig. 1), is a histamine H2-receptor antagonist widely used in the treatment of duodenal and gastric ulceration, gastroesophageal reflux disease and conditions of elevated gastric acidity, such as Zollinger-Ellison syndrome. However, massive overdose of ranitidine hydrochloride may cause side effects such as severe hepatotoxicity, hepatitis and disorder in visual accommodation. Therefore, the determination of ranitidine hydrochloride is of great importance in biological fluids and pharmaceutical formulations analysis. Numerous analytical techniques have been reported for the determination of ranitidine hydrochloride, which include high performance liquid chromatography, high pressure thin layer chromatography, fluorometry, spectrophotometry, titrimetry, flow-injection chemiluminescence, capillary zone electrophoresis, liquid chromatography-tandem mass spectrometry(LC-MS/MS) etc. Some of these reported methods suffer from disadvantages such as complicated procedure, long analysis time, expensive instrumentation and relatively low selectivity or sensitivity. Based on its electroactivity, ranitidine hydrochloride has also been investigated and determined conveniently by electrochemical methods. To our knowledge, voltammetric determinations of ranitidine hydrochloride at a graphene modified glassy carbon electrode have not been reported yet. Electrochemical Determination of Ranitidine Hydrochloride in Pharmaceutical Formulations and Biological Fluids at Graphene Modified Electrode