Liu Han-qing
2007
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Journal
Chinese Journal of Pharmaceuticals
Abstract
A HPLC method was established for the determination of the trans-isomer and R-isomer of mitiglinide calcium.For the former,a C18 column was used with the mobile phase of phosphoric acid(pH 2.5)-acetoni-trile(50∶50),at the detection wavelength of 210nm.For the latter,an OA-3300 chiral column was used with the mobile phase of normal hexane-chloroform-methanol-trifluoroacetic acid(25∶75∶1.5∶0.5),at the detection wavelength of 259nm.The limit detection of the trans-isomer and R-isomer were 0.08 and 0.51ng,respectively.