Qu Qian-feng
2005
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Influential Citations
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Journal
Chinese Journal of Pharmaceutical Analysis
Abstract
Objective: To establish a method for determination of five residual organic solvents in cefpiramide sodium. Method: Theresidual solvents in cefpiramide sodium are methanol, ethanol, acetone, acetonitrile, N, N-dimethylacetamide which were quantitatively determined by headspace solid-phase microextraction(SPME) GC on OV-1301 column,with FID detector,nitrogen as the carries. The SPME silica fiber was coated with a 95μm film of polymethylphenylvinylsiloxane/hydroxy-terminated silicone oil. Results: Five residual solvents were completely separated. There was a good linearity(r:0. 9992-0. 9999). The RSD of precision was less than 10%. The average recovery rate was in the range of 87.6%-101. 8%. The detection limits were between 0. 01-0. 2μg?mL~(-1). Conclusion: The method appeared to be rapid, sensitive and accurate, and can be used for quality control for the drug concerned.