L. Rui-pin
2014
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Journal
Journal of Pharmaceutical Research
Abstract
Objective To eastablish a method for the determination of seven residual solvents in cefcapene pivoxil hydrochloride and to investigate the technology. Methods Using N,N- dimethylformamide as solvent,achieved by the column of DB- 1701( 30 m × 0. 53 mm,1. 0 μm),N2as carrier gas,FID detector and programably tempreture. The initial tempreture was kept at 40 ℃ for 10 min,and the tempreture was raised to 180 ℃ at rate of 15 ℃ ·min- 1and lasted 5 min.Results Seven residual solvents was completely separated and there were good linearies( r = 0. 998 9 ~ 0. 999 8). The average recovery was in the range of 97. 9% ~ 103. 3%. Conclusion The method was simple,sensitive,accurate and reproducible,it can be used for the analysis of the organic solvents in bulk pharmaceuticals.