Huang Xiu-fen
2012
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Journal
Qilu Pharmaceutical Affairs
Abstract
Objective To establish a method for the determination of four residual solvents in ticarcillin disodium.Methods The residue levels of ethanol,acetonitrile,ethyl acetate and tetrahydrofuran in bulk drug of ticarcillin disodium were determined by headspace gas chromatography with Elite-5 apillary column,nitrogen as carrier gas,FID detector,water as solvent media and dichloroethane as inside standard.Results Four residual solvents were completely separated and had good linear relationships(r:0.995 3~0.995 9).The detection limits of ethanol,acetonitrile,ethyl acetate,tetrahydrofuran were 0.19,0.08,0.01,0.03 μg,respectively.The RSDs of precision were less than 5% and the average recoveries were 100.7%~102.7%.Conclusion The method was simple,sensitive,accurate and reproducible,it can be used for the determination of four residual solvents in bulk drug of Ticarcillin disodium.