L. Hjelmeland, L. Aronow, J. Trudell
Jul 1, 1977
Citations
0
Influential Citations
9
Citations
Journal
Molecular pharmacology
Abstract
Hydroxylation of monosubstituted 1,3-diphenylpropanes by rat liver microsomes leads predominantly to a mixture of the isomeric benzylic alcohols at positions 1 and 3. Quantitation of the relative concentrations of these alcohols can be achieved by combined gas chromatography-mass fragmentography. p -Methyl, p -trifluoromethyl, and p -fluoro substituents yield product distributions which clearly indicate an electrophilic mechanism for the hydroxylation reaction. ACKNOWLEDGMENTS The authors gratefully acknowledge the expert assistance of Dr. Elaine Herron and the Finnigan Corporation in obtaining mass fragmentograms.