J. T. Stewart, R. Wilkin
Mar 1, 1972
Citations
0
Influential Citations
12
Citations
Journal
Journal of pharmaceutical sciences
Abstract
Sulfonamides and local anesthetics containing a primary aromatic amino group react with 9-chloroacridine to yield aminoacridine hydrochlorides. The formation of these derivatives results in quenching of fluorescence of the 9-chloroacridine reagent solution. Monitoring the fluorescence at activation and emission wavelengths of 385 and 420 nm., respectively, enables one to analyze drug in the 10−5−10−6M range. The method was applied to various sulfonamides, local anesthetics, and mixtures of pharmaceuticals containing these entities. A comparative study of this technique was made with other known fluorometric procedures.