Y. Yildiz, A. Jan, L. Pendyala
Oct 20, 2017
Citations
0
Influential Citations
2
Citations
Journal
Journal name not available for this finding
Abstract
Trityl Candesartan (TCand), a benzimidazole derivative, is widely used in the preparation of Candesartan Cilexitil, a pharmaceutical prodrug created to treat hypertension and to help lower blood pressure. One major concern in the preparation process is the usage of tin compounds, specifically tributyl tin oxide, which can cause harm to both human and environmental health. In this study, UV-VIS Spectrophotometry was used for the simple and accurate determination of tin (Sn) in Trityl Candesartan. The study of Sn in Trityl Candesartan found the Sn content to be within the limit of 10 mg/Kg, with a correlation coefficient (R 2 ) of 0.9929, average percent recovery (%R) of 96.0%, and relative percentage difference (%RPD) of 0.35%.