Ming-jin Liang, Wei-Dong Zhang, Chuan Zhang
May 1, 2008
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Journal
Natural Product Communications
Abstract
The purpose of the present study was to evaluate the pharmacokinetic interaction of vitexin rhamnoside (vitexin 2″-α-L-rhamnopyranosyl) and vitexin glucoside (vitexin 2″-β-D-glucopyranosyl) in rats by using a high performance liquid chromatography coupled with tandem mass spectrometry quantitative detection method (LC-MS/MS). The method was validated at the concentration range of 5 - 5000 ng/mL for both vitexin rhamnoside and vitexin glucoside with the regression equations Y = 0.00181X - 0.000955 (r > 0.998) and Y = 0.000788X - 0.000373 (r > 0.997), respectively. The methodological studies (including linearity, intra-assay / inter-assay accuracy and precision) of these two components were investigated. The pharmacokinetic parameters of these two components were compared, which demonstrated their pharmacokinetic variance, especially when they were administrated simultaneously.