D. Qujeq, Homayoun Ahmadi
Aug 1, 2001
Citations
0
Influential Citations
3
Citations
Journal
American Journal of Nephrology
Abstract
Xanthopterin, a metabolic end product of the nonconjugated pteridine compound, is present in many organs and is known to inhibit the proliferation and growth of conconavalin-stimulated lymphocytes [1]. The purification and biochemical characterization of hitherto unrecognized fluorescence (excitation/emission maxima at 380/440 and 400/460 nm) reported in patients with chronic renal failure [2–4]. The hitherto undescribed fluorescence at Ex 380 nm/Em 440 nm and Ex 400 nm/ Em 460 nm was found the intensity being greatly increased in patients with chronic renal failure in comparison with normal subjects [5]. Xanthopterin, a known substrate of xanthine oxidase, had a strong effect on urate formation [6]. The physiological role of xanthopterin in the pathogenesis of uremia has yet to be elucidated [7]. The objective of this work was to determine the xanthopterin in patients with chronic renal failure.