S. K. Chin, R. Collier, D. Hutchinson
Sep 1, 1982
Citations
0
Influential Citations
1
Citations
Journal
Journal of Labelled Compounds and Radiopharmaceuticals
Abstract
The base-catalysed exchange of a proton of the methyl groups in acetanilides can be used to incorporate deuterium into these amides. 4′-Hydroxy-2[2H]acetanilide (acetaminophen, paracetamol) can be prepared by the demethylation with boron tribromide of 4′-methoxy-2[2H]acetamide obtained by this base-catalysed exchange.