H. Yousefnia, A. Jalilian, S. Zolghadri
Jan 14, 2015
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0
Influential Citations
10
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Journal
Journal of Radioanalytical and Nuclear Chemistry
Abstract
Particle emitter 1,4,7,10-tetraazacyclododecane-1,4,7,10 tetraethylene phosphonic acid complexes (DOTMP) are used for delivering high doses to bone marrow as well as palliative therapy. In this research production, quality control and biodistribution studies of [111In]-DOTMP with respect to its radiochemical and in vivo biological characteristics have been presented for imaging as well as dosimetry studies of therapeutic analogs. [111In]-DOTMP complex was obtained in high radiochemical purity (>99 %, ITLC) under at optimized conditions. This complex exhibited excellent in vitro stability at room temperature and human serum. Biodistribution studies in rats showed favorable selective skeletal uptake with rapid clearance from blood along with insignificant accumulation of activity in other non-target organs using tissue dissection and single-photon emission computed tomography (SPECT). This tracer can be used in the long term skeletal studies in SPECT procedures as well as presenting a dosimetry probe for therapeutic DOTMP analogs.