M. Yates, N. Kallman, Christopher P. Ley
Jan 12, 2009
Citations
0
Influential Citations
25
Citations
Journal
Organic Process Research & Development
Abstract
The synthesis of 5-bromo-thiophene-2-sulfonic acid 2,4-dichlorobenzoylamide sodium salt on multikilogram scale is described. The initial clinical supplies were made using carbonyl diimidazole to converge the two fragments. A more efficient acid chloride process has been developed, which also provides better control of impurities and color throughout the synthesis.