Taichiro Touge, M. Kuwana, Yasuhiro Komatsuki
Nov 22, 2018
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0
Influential Citations
28
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Journal
Organic Process Research & Development
Abstract
The development of an efficient synthetic route for an optically active ceramide compound (d-erythro-CER[NDS]) is described. The route proceeds through asymmetric transfer hydrogenation in a pipes-in-series flow reactor with oxo-tethered ruthenium complex-catalyzed dynamic kinetic resolution. This synthesis was accomplished without any expensive reagents, and none of the intermediates required isolation. This resulted in a robust process that has been successfully run on a production scale.