Kazutoshi Suzuki, Yuichirou Yoshida, N. Shikano
Jun 1, 1999
Citations
0
Influential Citations
15
Citations
Journal
Applied Radiation and Isotopes
Abstract
Abstract An automated system was developed to synthesize 13 N-labeled compounds with high specific activity using anhydrous [ 13 N]NH 3 as a synthetic precursor. This system enabled (1) production of an aqueous solution of [ 13 N]NH 3 , (2) concentration and desiccation of the [ 13 N]NH 3 solution, (3) reaction of anhydrous [ 13 N]NH 3 with substrate, (4) purification and formulation. By the use of this system, [ 13 N]p-nitrophenyl carbamate ([ 13 N]NPC) ready for i.v. injection could be obtained in 5.1±0.1 min at the yield of 3.5±0.4 GBq, specific activity 460±55 GBq/μmol, and radiochemical purity >99% ( n =3) by irradiating a 10 mM ethanol solution with 18 MeV protons at 17 μA for 25 min. With special precautions, [ 13 N]NPC could be obtained at the extremely high specific activity of 1800±200 GBq/μmol.