I. Hermecz
2003
Citations
0
Influential Citations
5
Citations
Journal
Advances in Heterocyclic Chemistry
Abstract
Publisher Summary This chapter surveys the recent development in the chemistry of pyrido-oxazines, pyrido-thiazines, pyrido-diazines, and their benzologs.. It discusses the ring systems, structure, thermodynamic aspects, theoretical calculations, spectroscopic properties, reactions, syntheses, and more briefly, utilization of the representatives of the ring systems of these compound. The chapter reviews the primary chemical literature of bicyclic 6-6 system, containing one ring junction nitrogen and one extra heteroatom, and their benzologs. The synthesis, pharmacology, pharmacokinetics and metabolism of compounds are reviewed in the chapter. The inhibition of human multidrug resistance P-glycoprotein 1 is examined in the chapter by analogs of a potent δ-opioid antagonist, including (3S,11aS)-3-[(4-hydroxy-2,6-dimethylphenyl)methyl]-11,11a-dihydro-2H-pyrazino[1,2-b]isoquinoline-1,4(3H,6H)-dione.