J. Hartung, Stephen N. Greszler, R. Klix
Sep 19, 2019
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Influential Citations
24
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Journal
Organic Process Research & Development
Abstract
The tetrasubstituted pyrrolidine core of ABBV-3221 was synthesized by catalytic, enantioselective cycloaddition. A Cu(I) catalyst system was identified as ideal for further development, which gave a 78% yield of 99% purity product after optimization. The processes of catalyst selection, optimization, and crystallization of the cycloaddition product are described herein.