S. Mohanty, Srinivasarao Talasila, A. K. Roy
Jan 2, 2014
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0
Influential Citations
2
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Journal
Organic Process Research & Development
Abstract
The main objective of this exercise was to develop a more efficient process for 2-(5-ethylpyridin-2-yl)ethan-1-ol (1), which is the key intermediate in the synthesis of pioglitazone hydrochloride. This process not only features the yield improvement of (1) by optimizing reaction variables in solvent-free conditions but also highlights improving the mass efficiency of 5-ethyl-2-picoline (2), thereby reducing the effluent load per kilogram of the intermediate.