H. Meckler, R. Herr
Mar 20, 2012
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Journal
Organic Process Research & Development
Abstract
A practical and scalable process is described for the preparation of 2-(methansulfonyl)benzenesulfonyl chloride, a key building block used in the synthesis of several drug candidates. The material is prepared by an efficient four-step sequence from inexpensive 1,2-dichlorobenzene and methanethiol, and the process has been demonstrated on a multikilogram scale in 32% overall yield with a chemical purity of >98%.