Jyun-Siao Chen, Yi-fan Ke, Heng-Yan Lin
Jan 19, 2021
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Influential Citations
2
Citations
Journal
Synthesis
Abstract
Abstract The trimethylsilyl (TMS) group is widely used in carbohydrate synthesis, although this protecting group is unstable and its post-synthetic purification challenging. The successful trimethylsilylation of carbohydrates mediated by recyclable and efficient acidic catalyst PTA/HMDS and the novel reagent, TMSOAc (TEA/TMSOAc), under alkaline condition is reported. The advantages of these methods are that the reactions proceed in good to excellent yields without applying column chromatography for purification.