Hiroshi Osato, M. Kabaki, S. Shimizu
Mar 16, 2011
Citations
0
Influential Citations
8
Citations
Journal
Organic Process Research & Development
Abstract
A safe, scalable process was developed for nitric acid oxidation of 3-bromo-2,2-bis(bromomethyl)propan-1-ol (2) to give 3-bromo-2,2-bis(bromomethyl)propanoic acid (3), an intermediate in the synthesis of S-013420 (1). The key points are the use of a catalytic amount of NaNO2 and addition of the starting material in portions. We achieved 3,000 L scale pilot production.