Annana, S. G, ankar
2014
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Abstract
Atazanavir sulfate (ATV) (3S,8S,9S,12S)-3,12-bis(1,1dimethylethyl)-8-hydroxy-4,11-dioxo-9-(phenylmethyl)-6[[4-(2-pyridinyl)phenyl]methyl]-2,5,6,10,13-pent-aazatetradecane dioic acid dimethyl ester (Fig. 1), an azapeptide is the 7 protease inhibitor used in the treatment of human immunodeficiency virus (HIV) Type II infection. Atazanavir sulfate is official in IP 2010. Atazanavir sulfate is reported as poorly water soluble and a known substrate for both hepatic metabolizing enzyme cytochrome 450 (CYP3A) and intestinal drug efflux pump, P-glycoprotein (Pgp) so have low oral bioavailability. In literature several methods of analysis are reported for determination of atazanavir sulfate in blood plasma, biological cells and cerebrospinal fluid by HPLC. Stress degradation studies which were reported, analyzed by HPLC and ultraviolet-spectrophotometry. The authors have reported spectrophotometric methods and HPLC method in pharmaceutical dosage form. The present work is developed to simplify the extractive spectrophotometric methods using two sulphonepthalein dyes, i.e. brormophenol blue and bromothymol blue.