Arsalan Mansoori, Fahimeh Zahednezhad, Ahad Bavili Tabrizi
Aug 31, 2019
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0
Influential Citations
2
Citations
Journal
Journal of the Iranian Chemical Society
Abstract
In the present study, we aimed to optimize the synthesis stages of S-pregabalin ((S)-3-(aminomethyl)-5-methylhexanoic acid), a well-known anticonvulsant drug. We used appropriate solvents and compounds to reach a straightforward and applicable method. The advantages of this research were avoiding use of expensive and environment pollutant reagents and solvents, and also using a recoverable reagent. Discarding prevention of the intermediates and reagents besides attaining a higher yield of the obtained product were the additional achievements. All structures were characterized by FT-IR, 1 H NMR, and the purity of S-pregabalin was evaluated using the HPLC assay.