Wang Canmin
2015
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Journal
Diabetes New World
Abstract
Mitiglinide is also called mitiglinide calcium, chemical name is Monocalcium bis [(2s)-2-benzyl-3-(cis-hexahydroisoindole-2-ylcarbonyl)- propionate] dehydrate. Mitiglinide is the third glimepiride drugs after repaglinide and nateglinide that are derivatives of phenylalanine, which mainly is used to improve Ⅱ diabetes postprandial hyperglycemia. In this paper, the asymmetric synthesis and chemical split method about the synthesis method of mitiglinide in recent years are outlined and compared.