Cheng Mao-sheng
2009
Citations
0
Influential Citations
1
Citations
Quality indicators
Journal
Journal of Shenyang Pharmaceutical University
Abstract
Objective To review the recent developments in erythromycin derivatives with new bioactivities.Methods According to the published papers and patents,the recent developments in erythromycin derivatives with new bioactivities were classified and summarized.Results Erythromycin and its derivatives had been widely used as antibacterial drugs for decades.Clinical and experimental data,however,indicated that they also have some new bioactivities,such as prokinetic effect,anti-inflammatory and immunomodulatory effect,luteinizing hormone-releasing hormone(LHRH) antagonistic effect and phosphodiesterase-3 inhibitory activity.In the effort to maximize these new activities of erythromycin while attenuate its anti-microbial effect,several series of novel erythromycin derivatives had been designed and synthesized.Conclusions The research and development of erythromycin derivatives with new bioactivities have gradually become an important part of erythromycin derivatives' research,which possess a good prospect.