D. Enders, Hongbin Sun, F. Leusink
May 7, 1999
Citations
0
Influential Citations
17
Citations
Journal
ChemInform
Abstract
Abstract An efficient asymmetric synthesis of 4-mono- and 3,4-disubstituted 2-acetoxy-butyrolactones 2 has been developed, based on a hydrazone-mediated asymmetric aldol reaction, an intramolecular lactonization and a stereoselective hydrogenation of the resulting butenolides 1 . An application of this process in the synthesis of the natural hunger substance 3 (ee = 90%) is also presented.