Stéphanie Fréville, P. Delbecq, V. T. Thuy
Jul 9, 2001
Citations
0
Influential Citations
27
Citations
Journal
Tetrahedron Letters
Abstract
Abstract A new diastereoselective synthesis of 2,6-disubstituted piperidinic alkaloids is presented. Three natural compounds, the (−)-pinidinone 1a , the (+)-dihydropinidine 1b and the (−)-pinidinol 1c were prepared from optically pure (6 R )-6-methylpiperidin-2-one 2 . This method is based on the chemo- and diastereocontrolled reductions of an exocyclic β-enamino ketone.