R. Schayer, J. Kennedy, R. Smiley
May 1, 1953
Citations
0
Influential Citations
11
Citations
Quality indicators
Journal
The Journal of biological chemistry
Abstract
Dibenaminel (N-(2-chloroethyl)dibenzylamine), a powerful adrenergic blocking agent, is known to modify the pharmacological effects of epinephrine and to reduce the toxicity (1). This laboratory has been studying the metabolism of epinephrine (24) and has shown the existence of at least five urinary metabolites. The problem of isolation and identification of these metabolites would be considerably simplified if Dibenamine-treated rats were employed, for this treatment permits a 2to 3-fold increase in the dose of epinephrine tolerated, with a corresponding increase in the quantity of urinary metabolites. We have therefore made an investigation on the effect of Dibenamine on the pattern of urinary metabolites and on the rate of metabolism of epinephrine.