E. Taylor, D. Kuhnt, C. Shih
Nov 13, 1992
Citations
5
Influential Citations
243
Citations
Quality indicators
Journal
Journal of medicinal chemistry
Abstract
N-[4-[2-(2-Amino-3,4-dihydro-4-oxo-7H-pyrrolo[2,3-d]pyrimidin-5- yl)ethyl]benzoyl]-L-glutamic acid (15), prepared in five steps from 2-pivaloyl-7-deazaguanine, has been found to be an antitumor agent with its primary site of action at thymidylate synthase rather than purine synthesis. This compound appears to be a promising candidate for clinical evaluation.