J. Barrett, A. Wong, J. Mclachlan
Jun 19, 1981
Citations
1
Influential Citations
187
Citations
Quality indicators
Journal
Science
Abstract
The frequency with which diethylstilbestrol induces neoplastic transformation and somatic mutation was measured concomitantly in Syrian hamster embryo cells. While diethylstilbestrol was as active as benzo[a]pyrene in inducing transformation, it failed to induce mutations at two conventionally studied loci. These results suggest that diethylstilbestrol may transform cells in the absence of gene mutations.