I. Teutsch, A. Weible, M. Siess
Dec 15, 1987
Citations
1
Influential Citations
21
Citations
Quality indicators
Journal
European journal of pharmacology
Abstract
1,2-Dioctanoylglycerol (10-100 microM) produced a positive inotropic effect on electrically stimulated left guinea pig atria and increased the frequency of spontaneously beating atria. Various phorbol esters and mezerein induced heterogeneous responses of the left atria. Phorbol dibutyrate and phorbol didecanoate decreased the force of contraction to different extents, whereas phorbol myristate acetate and mezerein had dual actions: an initial enhancement followed by a decline in force. None of these compounds changed the spontaneous atrial rate.