H. H. Harms, J. Zaagsma, J. de Vente
Jul 1, 1977
Citations
2
Influential Citations
73
Citations
Quality indicators
Journal
Life sciences
Abstract
Abstract In order to characterize the β-adrenoceptors in rat adipocytes in more detail, the β-adrenoceptor blocking potencies of the stereoisomers of propranolol, alprenolol, nifenalol and practolol were determined, using isoproterenol as the agonist, on β-adrenoceptors in isolated adipocytes, right atrium and hemidiaphragm of the rat. Marked differences in stereoselectivity of the four stereoisomer pairs were found in the three preparations and it is suggested that the β-adrenoceptors in the three preparations are not identical.